期刊
GENOME BIOLOGY
卷 11, 期 4, 页码 -出版社
BMC
DOI: 10.1186/gb-2010-11-4-r44
关键词
-
资金
- NSF [SGER-0714997]
- Partnership for Interdisciplinary Studies of Coastal Oceans (PISCO)
High-throughput genotype data can be used to identify genes important for local adaptation in wild populations, phenotypes in lab stocks, or disease-related traits in human medicine. Here we advance microarray-based genotyping for population genomics with Restriction Site Tiling Analysis. The approach simultaneously discovers polymorphisms and provides quantitative genotype data at 10,000s of loci. It is highly accurate and free from ascertainment bias. We apply the approach to uncover genomic differentiation in the purple sea urchin.
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