期刊
GENOME BIOLOGY
卷 11, 期 3, 页码 -出版社
BMC
DOI: 10.1186/gb-2010-11-3-r28
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资金
- National Institutes of Health [R01-LM006845]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [R01HG006677] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM083873] Funding Source: NIH RePORTER
- NATIONAL LIBRARY OF MEDICINE [R01LM006845] Funding Source: NIH RePORTER
Diploid genomes with divergent chromosomes present special problems for assembly software as two copies of especially polymorphic regions may be mistakenly constructed, creating the appearance of a recent segmental duplication. We developed a method for identifying such false duplications and applied it to four vertebrate genomes. For each genome, we corrected mis-assemblies, improved estimates of the amount of duplicated sequence, and recovered polymorphisms between the sequenced chromosomes.
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