期刊
GENOME BIOLOGY
卷 11, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2010-11-10-r99
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资金
- NIH Neuroscience Microarray Consortium [U24NS052108]
- NIMH [R01 MH071852]
- NHGRI [U01HG005210]
- NATIONAL HUMAN GENOME RESEARCH INSTITUTE [U01HG005210] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH071852] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [U24NS052108] Funding Source: NIH RePORTER
A primary component of next-generation sequencing analysis is to align short reads to a reference genome, with each read aligned independently. However, reads that observe the same non-reference DNA sequence are highly correlated and can be used to better model the true variation in the target genome. A novel short-read micro re-aligner, SRMA, that leverages this correlation to better resolve a consensus of the underlying DNA sequence of the targeted genome is described here.
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