期刊
GENOME BIOLOGY
卷 11, 期 3, 页码 -出版社
BMC
DOI: 10.1186/gb-2010-11-3-r30
关键词
-
资金
- NHGRI
- CIHR [81340, 84305]
- NSF [BDI-0345474]
- Ministry of Research and Innovation and CIHR [MOP-81340]
We systematically analyzed the relationships between gene fitness profiles (co-fitness) and drug inhibition profiles (co-inhibition) from several hundred chemogenomic screens in yeast. Co-fitness predicted gene functions distinct from those derived from other assays and identified conditionally dependent protein complexes. Co-inhibitory compounds were weakly correlated by structure and therapeutic class. We developed an algorithm predicting protein targets of chemical compounds and verified its accuracy with experimental testing. Fitness data provide a novel, systems-level perspective on the cell.
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