期刊
GENOME BIOLOGY
卷 10, 期 7, 页码 -出版社
BMC
DOI: 10.1186/gb-2009-10-7-r77
关键词
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资金
- Academy of Finland [120569, 8115939, 8116639, 127575]
- Sigrid Juselius Foundation
- Turku University Research Fund
The recent advent of exon microarrays has made it possible to reveal differences in alternative splicing events on a global scale. We introduce a novel statistical procedure that takes full advantage of the probe-level information on Affymetrix exon arrays when detecting differential splicing between sample groups. In comparison to existing ranking methods, the procedure shows superior reproducibility and accuracy in distinguishing true biological findings from background noise in high agreement with experimental validations.
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