期刊
GENOME BIOLOGY
卷 9, 期 3, 页码 -出版社
BMC
DOI: 10.1186/gb-2008-9-3-211
关键词
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NIAMS NIH HHS [K01 AR053573, K01AR053573] Funding Source: Medline
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [K01AR053573] Funding Source: NIH RePORTER
The immune system has evolved a plethora of innate receptors that detect microbial DNA and RNA, including Toll-like receptors in the endosomal compartment and RIG-I-like receptors and Nod-like receptors in the cytosol. Here we discuss the recognition of and responses to non-self nucleic acids via these receptors as well as their involvement in autoimmune diseases.
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