期刊
GENOME BIOLOGY
卷 9, 期 10, 页码 -出版社
BMC
DOI: 10.1186/gb-2008-9-10-r147
关键词
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资金
- NIH/NHGRI [GM076705]
- NSF Graduate Research Fellowship
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM076705] Funding Source: NIH RePORTER
Controlled simulations of genome evolution are useful for benchmarking tools. However, many simulators lack extensibility and cannot measure parameters directly from data. These issues are addressed by three new open-source programs: GSIMULATOR (for neutrally evolving DNA), SIMGRAM (for generic structured features) and SIMGENOME (for syntenic genome blocks). Each offers algorithms for parameter measurement and reconstruction of ancestral sequence. All three tools out-perform the leading neutral DNA simulator (DAWG) in benchmarks. The programs are available at http://biowiki.org/SimulationTools.
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