期刊
FRONTIERS IN PLANT SCIENCE
卷 5, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fpls.2014.00083
关键词
chromatin; epigenetics; ubiquitin; histone monoubiquitination; transcription regulation; plant development; Arabidopsis thaliana
资金
- French Centre National de la Recherche Scientifique(CNRS)
- French Agence Nationale de la Recherche [ANR-08-BLAN-0200-CSD7, ANR-12-BSV2-0013-02]
- China Scholarship Council of the Ministry of Education of P. R. China
- Agence Nationale de la Recherche (ANR) [ANR-08-BLAN-0200] Funding Source: Agence Nationale de la Recherche (ANR)
Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and is in nowadays recognized as one critical type of epigenetic marks in eukaryotes. While H2A monoubiquitination (H2Aub1) is generally associated with transcription repression mediated by the Polycomb pathway, H2Bub1 is involved in transcription activation. H2Aub1 and H2Bub1 levels are dynamically regulated via deposition and removal by specific enzymes. We review knows and unknowns of dynamic regulation of H2Aub1 and H2Bub1 deposition and removal in plants and highlight the underlying crucial functions in gene transcription, cell proliferation/differentiation, and plant growth and development. We also discuss crosstalks existing between H2Aub1 or H2Bub1 and different histone methylations for an ample mechanistic understanding.
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