期刊
FRONTIERS IN MICROBIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmicb.2018.01680
关键词
lymphoma; Hodgkin's lymphoma; anellovirus; torque teno mini virus (TTMV); viral metagenomics
类别
资金
- National Key Project for Infectious Diseases of China [2012ZX10002-006, 2012ZX10004-503, 2012ZX10002012-003, 2018ZX10301208]
- National Basic Research Program of China [2012CB519002]
- National High-Tech Program of China [2012AA02A407]
- Natural Science Foundation of China [81472226, 31170148, 81470737]
- [FDMV-2017002]
At least 12% of human cancers are caused by virus infection. To understand whether other viruses are associated with human cancers, a viral metagenomics approach was used to analyze the composition of the viral communities of the serum of the patients with Hodgkin's lymphoma (HL) and non-Hodgkin lymphoma. In this report, a human anellovirus TTMV named TTMV-SH was discovered from three patients with HL. The complete genome of TTMV-SH is 2812nt in length. Phylogenetic analysis based on ORF1 indicated that TTMV-SH of the 11 isolates cluster with TTMV strain TLMV-CBD231 sharing only 60.3-62% sequence similarity, and the sequences divergence is 41.5-43.1%, which indicates that TTMV-SH is a novel species. The TTMV-SH prevalence in HL group, especially in nodular sclerosing Hodgkin's lymphomas (NSHL), was significantly higher than in the healthy group implicated that the TTMV-SH may be associated with HL, especially NSHL.
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