期刊
FRONTIERS IN MICROBIOLOGY
卷 4, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fmicb.2013.00283
关键词
Photobacterium damselae; hemolysin; damselysin; hlyA; pore-forming toxin
类别
资金
- Xunta de Galicia, Spain [EM2012/043]
- Ministry of Economy and Competitiveness (MINECO) of Spain [AGL2012-39274-C02-01]
- Ministry of Science and Innovation (MICINN) of Spain (Consolider Aquagenomics) [CSD2007-00002]
- European Union
Photobacterium damselae subsp. damselae (formerly Vibrio damsela) is a pathogen of a variety of marine animals including fish, crustaceans, molluscs, and cetaceans. In humans, it can cause opportunistic infections that may evolve into necrotizing fasciitis with fatal outcome. Although the genetic basis of virulence in this bacterium is not completely elucidated, recent findings demonstrate that the phospholipase-D Dly (damselysin) and the pore-forming toxins HlyA(pl) and HlyA(ch) play a main role in virulence for homeotherms and poikilotherms. The acquisition of the virulence plasmid pPHDD1 that encodes Dly and HlyApi has likely constituted a main driving force in the evolution of a highly hemolytic lineage within the subspecies. Interestingly, strains that naturally lack pPHDD1 show a strong pathogenic potential for a variety of fish species, indicating the existence of yet uncharacterized virulence factors. Future and deep analysis of the complete genome sequence of Photobacterium damselae subsp. damselae will surely provide a clearer picture of the virulence factors employed by this bacterium to cause disease in such a varied range of hosts.
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