期刊
ANNUAL REVIEW OF VIROLOGY, VOL 2
卷 2, 期 -, 页码 181-201出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-031413-085446
关键词
horizontal gene transfer; bacteriophage; pathogenicity island; molecular piracy; evolution; virulence
类别
资金
- MRC [MR/M003876/1] Funding Source: UKRI
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R56AI081837] Funding Source: NIH RePORTER
- Medical Research Council [MR/M003876/1] Funding Source: Medline
- NIAID NIH HHS [1R56 AI081837] Funding Source: Medline
The phage-inducible chromosomal islands (PICIs) are a family of highly mobile genetic elements that contribute substantively to horizontal gene transfer, host adaptation, and virulence. Initially identified in Staphylococcus aureus, these elements are now thought to occur widely in gram-positive bacteria. They are molecular parasites that exploit certain temperate phages as helpers, using a variety of elegant strategies to manipulate the phage life cycle and promote their own spread, both intra-and intergenerically. At the same time, these PICI-encoded mechanisms severely interfere with helper phage reproduction, thereby enhancing survival of the bacterial population. In this review we discuss the genetics and the life cycle of these elements, with special emphasis on how they interact and interfere with the helper phage machinery for their own benefit. We also analyze the role that these elements play in driving bacterial and viral evolution.
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