期刊
ANNUAL REVIEW OF VIROLOGY, VOL 2
卷 2, 期 -, 页码 497-524出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-100114-055238
关键词
high-throughput screening; RNA interference; haploid genetic screens; gain-of-function screens; pro-viral host factors; antiviral host factors
类别
Deciphering the many interactions that occur between a virus and host cell over the course of infection is paramount to understanding mechanisms of pathogenesis and to the future development of antiviral therapies. Over the past decade, researchers have started to understand these complicated relationships through the development of methodologies, including advances in RNA interference, proteomics, and the development of genetic tools such as haploid cell lines, allowing high-throughput screening to identify critical contact points between virus and host. These advances have produced a wealth of data regarding host factors hijacked by viruses to promote infection, as well as antiviral factors responsible for subverting viral infection. This review highlights findings from virus-host screens and discusses our thoughts on the direction of screening strategies moving forward.
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