期刊
FRONTIERS IN MICROBIOLOGY
卷 1, 期 -, 页码 -出版社
FRONTIERS RESEARCH FOUNDATION
DOI: 10.3389/fmicb.2010.00107
关键词
phosphorylation; prolyl-isomerization; protein stability; Pin1
类别
资金
- Takeda Science Foundation
- Japanese Ministry of Education
- Japanese Ministry of Culture
- Japanese Ministry of Sports
- Japanese Ministry of Science
- Japanese Ministry of Technology
Pin1 is an enzyme that specifically catalyzes the cis-trans isomerization of phosphorylated serine/threonine-proline (pSer/Thr-Pro) motif in its substrate proteins. Recent studies demonstrate that stability of several viral proteins is regulated by phosphorylation-dependent prolyl-isomerization by a host factor Pin1. Pin1 is now positioned as an important modulator of the molecular crosstalk between virus and host cells and could be a unique target for anti-virus therapy. This new type of post-translational modification by Pin1 might be involved in the regulation of other viral proteins.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据