期刊
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
卷 2, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fcimb.2012.00121
关键词
Leishmania; macrophage; phagosome; virulence; lipophosphoglycan
资金
- Canadian Institutes of Health Research [MOP-12933]
- Canada Research Chairs program
- Fondation Armand-Frappier
Upon their internalization by macrophages, Leishmano promastigotes inhibit phagolysosome biogenesis. The main factor responsible for this inhibition is the promastigote surface glycolipid lipophosphoglycan (LPG). This glycolipid has a profound impact on the phagosome, causing periphagosomal accumulation of F-actin and disruption of phagosomal lipid microdomains. Functionally, this [PG mediated inhibition of phagosome maturation is characterized by an impaired assembly of the NADPH oxidase and the exclusion of the vesicular proton-ATPase from phagosomes. In this chapter, we review the current knowledge concerning the nature of the intra-macrophage compartment in which Leishmania danavani promastigotes establish infection. We also describe how LPG enables this parasite to remodel the parasitophorous vacuole.
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