期刊
EXPERIMENTAL BRAIN RESEARCH
卷 215, 期 3-4, 页码 359-367出版社
SPRINGER
DOI: 10.1007/s00221-011-2903-9
关键词
Unstable object manipulation; Precision grip; Grasping network; Motor cortex; Cerebellum
资金
- Swedish Research Council [5925]
- Swedish Foundation for Strategic Research
- VINNOVA
- Foundation Frimurare Barnhuset
- Karolinska Institutet and Knut
- Alice Wallenberg
- Foundation Stiftelsen Olle Engkvist Byggmastare
- EU
- [NSF 0237258]
- [NIH HD048566]
- [AR050520]
Multifinger dexterous manipulation of unstable or deformable objects requires control of both direction and magnitude of fingertip force vectors. Our aim was to study the neuroanatomical correlates of these two distinct control functions. Brain activity was measured using functional magnetic resonance imaging while 16 male subjects (age: 26-42, M = 32, SD +/- A 4 years) compressed four springs representing a 2 x 2 factorial design with two levels of force and instability requirements. Significant activations associated with higher instability were located bilaterally in the precentral gyri, the postcentral gyrus, and the cerebellum. In the main effect for high force, activity was found in areas located in the primary motor regions contralateral to the active hand and bilaterally in the cerebellum. An overlap in activation between the two main effects was found bilaterally in the cerebellum (lobule VI). This study not only confirms a recently described bilateral fronto-parieto-cerebellar network for manipulation of increasingly unstable objects, but critically extends our understanding by describing its differentiated modulation with both force magnitude and instability requirements. Our results, therefore, expose a previously unrecognized and context-sensitive system of brain regions that enable dexterous manipulation for different force magnitude and instability requirements of the task.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据