期刊
EXPERIMENTAL BRAIN RESEARCH
卷 193, 期 4, 页码 581-589出版社
SPRINGER
DOI: 10.1007/s00221-008-1660-x
关键词
All-trans-retinoic acid; Cerebral ischemia; Inflammation; Cyclooxygenase-2; C/EBP beta
资金
- Medical Research Institute Grant [2006-11]
- Pusan National University
- MRC program of MOST/KOSEF [R13-2005-009]
Ischemia-induced cerebral injury evolves over a longer period than previously believed through post-ischemic inflammation. Retinoic acid (RA) has been shown to exert cytoprotective effects on several cells, but its effects on ischemia-induced cerebral injury have been poorly characterized. The aim of the present study was to examine the effects of all-trans-RA on ischemia-induced cerebral injury and elucidate the underlying mechanism. All-trans-RA treatment reduced the size of the ischemia-induced cerebral infarct. To elucidate the underlying mechanism, ischemia-induced cerebral inflammation was studied by examination of expressions of interleukin 1 beta (IL-1 beta) and ED-1. RA treatment significantly reduced the cerebral inflammation. Moreover, cerebral ischemic induction of cyclooxygenase-2 (COX-2) and CCAAT/enhancer binding protein beta (C/EBP beta), which binds to the COX-2 promoter, was also inhibited by RA. These results suggest that RA can reduce ischemia-induced cerebral injury by an anti-inflammatory action, which may be effected via inhibition of C/EBP beta-mediated COX-2 induction.
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