期刊
ELIFE
卷 3, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.02809
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类别
资金
- Juvenile Diabetes Research Foundation post-doctoral fellowships
- Howard Hughes Medical Institute
Dysfunction or death of pancreatic beta cells underlies both types of diabetes. This functional decline begins with beta cell stress and de-differentiation. Current drugs for T2D lower blood glucose levels, but do not directly alleviate beta cell stress nor prevent, let alone reverse, beta cell de-differentiation. We show here that Urocortin 3 (Ucn3), a marker for mature beta cells, is down-regulated in the early stages of T2D in mice and when beta cells are stressed in vitro. Using an insulin expression-coupled lineage tracer, with Ucn3 as a reporter for the mature beta cell state, we screen for factors that reverse beta cell de-differentiation. We find that a small molecule inhibitor of TGF beta receptor I (Alk5) protects cells from the loss of key beta cell transcription factors and restores a mature beta cell identity even after exposure to prolonged and severe diabetes.
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