期刊
ELIFE
卷 3, 期 -, 页码 -出版社
eLIFE SCIENCES PUBL LTD
DOI: 10.7554/eLife.03125
关键词
SUP05; bacteriophages; viruses; single cell genomics; oxygen minimum zones; viral dark matter
类别
资金
- U.S. Department of Energy Joint Genome Institute - Office of Science of the U.S. Department of Energy [DE-AC02-05CH11231]
- G. Unger Vetlesen Foundation
- Ambrose Monell Foundation
- Tula Foundation - Centre for Microbial Diversity and Evolution
- Natural Sciences and Engineering Research Council (NSERC) of Canada
- Canada Foundation for Innovation (CFI)
- Canadian Institute for Advanced Research (CIFAR)
- BIO5, NSF [OCE-0961947]
- Gordon and Betty Moore Foundation [3790]
- NSF [OCE-821374, OCE-1019242]
- State of Maine Technology Institute
- Directorate For Geosciences
- Division Of Ocean Sciences [1232982] Funding Source: National Science Foundation
- Directorate For Geosciences
- Division Of Ocean Sciences [1136488] Funding Source: National Science Foundation
Viruses modulate microbial communities and alter ecosystem functions. However, due to cultivation bottlenecks specific virus-host interaction dynamics remain cryptic. Here we examined 127 single-cell amplified genomes (SAGs) from uncultivated SUP05 bacteria isolated from a marine oxygen minimum zone (OMZ) to identify 69 viral contigs representing five new genera within dsDNA Caudovirales and ssDNA Microviridae. Infection frequencies suggest that similar to 1/3 of SUP05 bacteria are viral-infected, with higher infection frequency where oxygen-deficiency was most severe. Observed Microviridae clonality suggests recovery of bloom-terminating viruses, while systematic co-infection between dsDNA and ssDNA viruses posits previously unrecognized cooperation modes. Analyses of 186 microbial and viral metagenomes revealed that SUP05 viruses persisted for years, but remained endemic to the OMZ. Finally, identification of virus-encoded dissimilatory sulfite reductase suggests SUP05 viruses reprogram their host's energy metabolism. Together these results demonstrate closely coupled SUP05 virus-host co-evolutionary dynamics with potential to modulate biogeochemical cycling in climate-critical and expanding OMZs.
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