相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Structure of the human smoothened receptor bound to an antitumour agent
Chong Wang et al.
NATURE (2013)
Structural basis for molecular recognition of folic acid by folate receptors
Chen Chen et al.
NATURE (2013)
Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
Daniel Nedelcu et al.
NATURE CHEMICAL BIOLOGY (2013)
The mechanisms of Hedgehog signalling and its roles in development and disease
James Briscoe et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity
Yu Wang et al.
CHEMISTRY & BIOLOGY (2012)
Structural Architecture and Functional Evolution of Wnts
J. Fernando Bazan et al.
DEVELOPMENTAL CELL (2012)
Crystal Structure of N-Glycosylated Human Glypican-1 Core Protein STRUCTURE OF TWO LOOPS EVOLUTIONARILY CONSERVED IN VERTEBRATE GLYPICAN-1
Gabriel Svensson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
SIGNALING An oxysterol ligand for Smoothened
Hayley J. Sharpe et al.
NATURE CHEMICAL BIOLOGY (2012)
Oxysterols are allosteric activators of the oncoprotein Smoothened
Sigrid Nachtergaele et al.
NATURE CHEMICAL BIOLOGY (2012)
Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome
Jean Y. Tang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Cysteine-rich domains related to Frizzled receptors and Hedgehog-interacting proteins
Jimin Pei et al.
PROTEIN SCIENCE (2012)
Structural Basis of Wnt Recognition by Frizzled
Claudia Y. Janda et al.
SCIENCE (2012)
Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance
Gerrit J. P. Dijkgraaf et al.
CANCER RESEARCH (2011)
Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome
Ashish K. Maurya et al.
DEVELOPMENT (2011)
Ligand-based receptor tyrosine kinase partial agonists: new paradigm for cancer drug discovery?
David J. Riese
EXPERT OPINION ON DRUG DISCOVERY (2011)
Novel Oxysterols Have Pro-Osteogenic and Anti-Adipogenic Effects In Vitro and Induce Spinal Fusion In Vivo
Jared S. Johnson et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2011)
Automation of large scale transient protein expression in mammalian cells
Yuguang Zhao et al.
JOURNAL OF STRUCTURAL BIOLOGY (2011)
Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
Kunyoo Shin et al.
NATURE (2011)
Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling
Min-Sung Kim et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
XDS
Wolfgang Kabsch
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)
Itraconazole, a Commonly Used Antifungal that Inhibits Hedgehog Pathway Activity and Cancer Growth
James Kim et al.
CANCER CELL (2010)
Identification of Surface Residues on Niemann-Pick C2 Essential for Hydrophobic Handoff of Cholesterol to NPC1 in Lysosomes
Michael L. Wang et al.
CELL METABOLISM (2010)
xia2: an expert system for macromolecular crystallography data reduction
G. Winter
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2010)
GDC-0449-A potent inhibitor of the hedgehog pathway
Kirk D. Robarge et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2009)
Structural Ties between Cholesterol Transport and Morphogen Signaling
J. Fernando Bazan et al.
CELL (2009)
Structure of N-Terminal Domain of NPC1 Reveals Distinct Subdomains for Binding and Transfer of Cholesterol
Hyock Joo Kwon et al.
CELL (2009)
The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling
Pia Aanstad et al.
CURRENT BIOLOGY (2009)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Crystal Structure of the Frizzled-Like Cysteine-Rich Domain of the Receptor Tyrosine Kinase MuSK
Amy L. Stiegler et al.
JOURNAL OF MOLECULAR BIOLOGY (2009)
Evidence for Allosteric Interactions of Antagonist Binding to the Smoothened Receptor
Cynthia M. Rominger et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Inhibition of the Hedgehog Pathway in Advanced Basal-Cell Carcinoma.
Daniel D. Von Hoff et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
PubChem: a public information system for analyzing bioactivities of small molecules
Yanli Wang et al.
NUCLEIC ACIDS RESEARCH (2009)
Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process
Rajat Rohatgi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma
Robert L. Yauch et al.
SCIENCE (2009)
Mechanisms of Hedgehog pathway activation in cancer and implications for therapy
Suzie J. Scales et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2009)
Clustal W and clustal X version 2.0
M. A. Larkin et al.
BIOINFORMATICS (2007)
20(S)-Hydroxycholesterol inhibits PPARγ expression and adipogenic differentiation of bone marrow stromal cells through a hedgehog-dependent mechanism
Woo-Kyun Kim et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2007)
Phaser crystallographic software
Airlie J. McCoy et al.
JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)
Patched1 regulates Hedgehog signaling at the primary cilium
Rajat Rohatgi et al.
SCIENCE (2007)
MolProbity: all-atom contacts and structure validation for proteins and nucleic acids
Ian W. Davis et al.
NUCLEIC ACIDS RESEARCH (2007)
Oxysterols pathway in are novel activators of the hedgehog pluripotent mesenchymal cells
Jennifer R. Dwyer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Design and synthesis of fluconazole/bile acid conjugate using click reaction
Vandana S. Pore et al.
TETRAHEDRON (2006)
A time- and cost-efficient system for high-level protein production in mammalian cells
A. Radu Aricescu et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Solvent-induced amphiphilic molecular baskets: Unimolecular reversed micelles with different size, shape, and flexibility
Eui-Hyun Ryu et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Asymmetric synthesis of enantioenriched (+)-elaeokanine A
R. Karl Dieter et al.
JOURNAL OF ORGANIC CHEMISTRY (2006)
Oxysterols stimulate Sonic hedgehog signal transduction and proliferation of medulloblastoma cells
Ryan B. Corcoran et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Divergence of hedgehog signal transduction mechanism between Drosophila and mammals
M Varjosalo et al.
DEVELOPMENTAL CELL (2006)
Scaling and assessment of data quality
P Evans
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2006)
Oligomeric cholates: Amphiphilic foldamers with nanometer-sized hydrophilic cavities
Y Zhao et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2005)
Vertebrate Smoothened functions at the primary cilium
KC Corbit et al.
NATURE (2005)
A procedure for setting up high-throughput nanolitre crystallization experiments. Crystallization workflow for initial screening, automated storage, imaging and optimization
TS Walter et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2005)
Solution structure of the E. coli TolA C-terminal domain reveals conformational changes upon binding to the phage g3p N-terminal domain
C Deprez et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Benefits of automated crystallization plate tracking, imaging, and analysis
CJ Mayo et al.
STRUCTURE (2005)
Oxysterols regulate differentiation of mesenchymal stem cells: Pro-bone and anti-fat
HT Kha et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2004)
Refinement of severely incomplete structures with maximum likelihood in BUSTER-TNT
E Blanc et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Coot:: model-building tools for molecular graphics
P Emsley et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)
Functional domains and sub-cellular distribution of the Hedgehog transducing protein Smoothened in Drosophila
Y Nakano et al.
MECHANISMS OF DEVELOPMENT (2004)
Sonic hedgehog is required for progenitor cell maintenance in telencephalic stem cell niches
R Machold et al.
NEURON (2003)
Multiple muscle cell identities induced by distinct levels and timing of hedgehog activity in the zebrafish embryo
C Wolff et al.
CURRENT BIOLOGY (2003)
The G-protein-coupled receptors in the human genome form five main families.: Phylogenetic analysis, paralogon groups, and fingerprints
R Fredriksson et al.
MOLECULAR PHARMACOLOGY (2003)
SOLVE and RESOLVE: Automated structure solution and density modification
TC Terwilliger
MACROMOLECULAR CRYSTALLOGRAPHY, PT D (2003)
Atomic resolution structure of Moloney murine leukemia virus matrix protein and its relationship to other retroviral matrix proteins
N Riffel et al.
STRUCTURE (2002)
Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened
JK Chen et al.
GENES & DEVELOPMENT (2002)
PHENIX:: building new software for automated crystallographic structure determination
PD Adams et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2002)
Small molecule modulation of Smoothened activity
JK Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Substructure solution with SHELXD
TR Schneider et al.
ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2002)
Patched acts catalytically to suppress the activity of Smoothened
J Taipale et al.
NATURE (2002)
Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur
J Brown et al.
EMBO JOURNAL (2002)
Insights into Wnt binding and signalling from the structures of two Frizzled cysteine-rich domains
CE Dann et al.
NATURE (2001)
Transmembrane molecular pump activity of Niemann-Pick C1 protein
JP Davies et al.
SCIENCE (2000)
Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine
J Taipale et al.
NATURE (2000)
分享论文
