期刊
ELIFE
卷 2, 期 -, 页码 -出版社
ELIFE SCIENCES PUBLICATIONS LTD
DOI: 10.7554/eLife.00675
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资金
- Department of Energy [DE-FG03-00ER15113, DE-FG02-04ER15517]
- National Science Foundation [MCB-0924871, MCB-1024999]
- Canadian Institutes of Health Research [MOP-111007]
- National Science Foundation, Plant Systems Biology IGERT [DGE-0504645]
- National Institutes of Health [1RO1 GM085022]
- National Institutes of Health, NRSA [F32-HG004830]
- Howard Hughes Medical Institute
- Gordon and Betty Moore Foundation [GBMF3034]
- Gates Millenium Scholarship
- U.S. Department of Energy (DOE) [DE-FG02-04ER15517] Funding Source: U.S. Department of Energy (DOE)
- Direct For Biological Sciences
- Div Of Molecular and Cellular Bioscience [1024999] Funding Source: National Science Foundation
The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways.
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