期刊
CURRENT RHEUMATOLOGY REPORTS
卷 13, 期 1, 页码 44-50出版社
SPRINGER
DOI: 10.1007/s11926-010-0143-9
关键词
Systemic sclerosis; Scleroderma; Interstitial lung disease; Biomarkers; SP-D; KL-6; TWEAK; APRIL; BAFF; Exhaled nitric oxide; PMN elastase
类别
This article reviews the clinical background and significance of selected biomarkers that have been studied in relation to systemic sclerosis, or scleroderma, a devastating connective tissue disease whose morbidity and mortality are often related to pulmonary complications. Interstitial lung disease is the most common pulmonary manifestation in systemic sclerosis, and the search for a noninvasive biomarker to assess and monitor patients and their lung disease is a nascent and expending field of study. In this article, we examine the background and significance of a variety of selected biomarkers and assess their role in relation to systemic sclerosis-related interstitial lung disease.
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