期刊
CLINICAL EPIGENETICS
卷 10, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13148-018-0550-8
关键词
MAGE; Epigenetics; Transcription regulator; E3 RING ubiquitin ligases
资金
- Nature Science Foundation of Hebei Province [2016206410]
The melanoma antigen gene (MAGE) proteins are a group of highly conserved family members that contain a common MAGE homology domain. Type I MAGEs are relevant cancer-testis antigens (CTAs), and originally considered as attractive targets for cancer immunotherapy due to their typically high expression in tumor tissues but restricted expression in normal adult tissues. Here, we reviewed the recent discoveries and ideas that illustrate the biological functions of MAGE family in cancer progression. Furthermore, we also highlighted the current understanding of the epigenetic mechanism of MAGE family expression in human cancers.
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