4.2 Review

Atrial Natriuretic Peptide and Renal Dopaminergic System: A Positive Friendly Relationship?

期刊

BIOMED RESEARCH INTERNATIONAL
卷 2014, 期 -, 页码 -

出版社

HINDAWI LTD
DOI: 10.1155/2014/710781

关键词

-

资金

  1. National Scientific and Technical Research Council (CONICET) [PIP 1337]
  2. ANPCYT [PICT 2012-1775]
  3. Universidad de Buenos Aires [UBACYT 20020100100688, 20020110200048]
  4. Sociedad Argentina de Hipertension Arterial (Stimulus Grant for Research on Hypertension)

向作者/读者索取更多资源

Sodium metabolism by the kidney is accomplished by an intricate interaction between signals from extrarenal and intrarenal sources and between antinatriuretic and natriuretic factors. Renal dopamine plays a central role in this interactive network. The natriuretic hormones, such as the atrial natriuretic peptide, mediate some of their effects by affecting the renal dopaminergic system. Renal dopaminergic tonus can be modulated at different steps of dopamine metabolism (synthesis, uptake, release, catabolism, and receptor sensitization) which can be regulated by the atrial natriuretic peptide. At tubular level, dopamine and atrial natriuretic peptide act together in a concerted manner to promote sodium excretion, especially through the overinhibition of Na+, K+-ATPase activity. In this way, different pathological scenarios where renal sodium excretion is dysregulated, as in nephrotic syndrome or hypertension, are associated with impaired action of renal dopamine and/or atrial natriuretic peptide, or as a result of impaired interaction between these two natriuretic systems. The aim of this review is to update and comment on the most recent evidences demonstrating how the renal dopaminergic system interacts with atrial natriuretic peptide to control renal physiology and blood pressure through different regulatory pathways.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.2
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据