期刊
BIOMED RESEARCH INTERNATIONAL
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/687469
关键词
-
资金
- National Basic Research Program of China [2011CB504405]
- National High Technology Research and Development Program of China [2012AA011602]
- National Natural Science Foundation (NSF) of China [61233015]
- National NSF of China [61103107, 61001172, 61003150, 61305145, 61305146, 31371001]
- Specialized Research Fund for the Doctoral Program of Higher Education [20100101120104, 20100101120154, 20100101120166]
- Fundamental Research Funds for the Central Universities
- Zhejiang provincial international science and technology cooperation program [2012C24025]
The ventral tegmental area (VTA) plays an important role in motivation and motor activity of mammals. Previous studies have reported that electrical stimulations of the VTA's neuronal projections were able to upregulate the locomotor activity of behaving rats. However, which types of neurons in the VTA that take part in the activation remain elusive. In this paper we employed optogenetic technique to selectively activate the excitatory neurons expressing CaMKII alpha in the VTA region and induced a higher locomotor activity for free behaving rats. Further behavioral studies indicated that reward learning mediated in the enhancement of the rat locomotor activity. Finally the immunohistochemistry studies explored that the excitatory neurons under the optogenetic activation in VTA were partly dopaminergic that may participate as a vital role in the optogenetic activation of the locomotor activity. In total, our study provided an optogenetic approach to selectively upregulate the locomotor activity of free behaving rats, thus facilitating both neuroscience researches and neural engineering such as animal robotics in the future.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据