期刊
BIOMED RESEARCH INTERNATIONAL
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/153808
关键词
-
资金
- Project TRIBONE [11458]
- European Community FEDER fund
- program COMPETE: Programa Operacional Factores de Competitividade [Pest-OE/AGR/UI0211/2011]
- Projects QREN I&DT Cluster in Development of Products for Regenerative Medicine and Cell Therapie
- Projects Biomat Cell [QREN 2008/1372]
- Sanyo Broadcasting Gakujyutsu Bunka Foundation. This project was also cofinanced by the European Community FEDER fund [20072013]
- FCT, and Ministerio da Educacao e da Ciencia and Program Project Euronanomed [ENMED/0002/2010]
The treatment of peripheral nerve injuries remains one of the greatest challenges of neurosurgery, as functional recover is rarely satisfactory in these patients. Recently, biodegradable nerve guides have shown great potential for enhancing nerve regeneration. A major advantage of these nerve guides is that no foreign material remains after the device has fulfilled its task, which spares a second surgical intervention. Recently, we studied peripheral nerve regeneration using chitosan-gamma-glycidoxypropyltrimethoxysilane (chitosan-GPTMS) porous hybrid membranes. In our studies, these porous membranes significantly improved nerve fiber regeneration and functional recovery in rat models of axonotmetic and neurotmetic sciatic nerve injuries. In particular, the number of regenerated myelinated nerve fibers and myelin thickness were significantly higher in rat treated with chitosan porous hybrid membranes, whether or not they were used in combination with mesenchymal stem cells isolated from the Wharton's jelly of the umbilical cord. In this review, we describe our findings on the use of chitosan-GPTMS hybrids for nerve regeneration.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据