期刊
BIOMED RESEARCH INTERNATIONAL
卷 2014, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2014/731039
关键词
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资金
- Young Start-up Project for Medical Science Development
- Nanjing Health Bureau [QYK10166]
- Key Project of Science and Technology Bureau of Jiangsu Province [BL2013002]
- International Cooperation Research and Develop Project of Nanjing Health Bureau [201303051]
Periodontitis is an inflammatory disease characterized by periodontal pocket formation and alveolar bone resorption. Periodontal bone resorption is induced by osteoclasts and receptor activator of nuclear factor-kappa B ligand (RANKL) which is an essential and central regulator of osteoclast development and osteoclast function. Therefore, RANKL plays a critical role in periodontal bone resorption. In this review, we have summarized the sources of RANKL in periodontal disease and explored which factors may regulate RANKL expression in this disease.
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