4.2 Article

Unique Pattern of Component Gene Disruption in the NRF2 Inhibitor KEAP1/CUL3/RBX1 E3-Ubiquitin Ligase Complex in Serous Ovarian Cancer

相关参考文献

注意:仅列出部分参考文献,下载原文获取全部文献信息。
Article Otorhinolaryngology

Disruption of KEAP1/CUL3/RBX1 E3-ubiquitin ligase complex components by multiple genetic mechanisms: Association with poor prognosis in head and neck cancer

Victor D. Martinez et al.

HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK (2015)

Article Biochemistry & Molecular Biology

Kinetic, Thermodynamic, and Structural Characterizations of the Association between Nrf2-DLGex Degron and Keap1

Toshiaki Fukutomi et al.

MOLECULAR AND CELLULAR BIOLOGY (2014)

Review Pharmacology & Pharmacy

Role of Nrf2 in Oxidative Stress and Toxicity

Qiang Ma

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 53, 2013 (2013)

Article Medicine, Research & Experimental

Prognostically relevant gene signatures of high-grade serous ovarian carcinoma

Roel G. W. Verhaak et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Cell Biology

Mechanisms and function of substrate recruitment by F-box proteins

Jeffrey R. Skaar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Regulatory flexibility in the Nrf2-mediated stress response is conferred by conformational cycling of the Keap1-Nrf2 protein complex

Liam Baird et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)

Article Biochemistry & Molecular Biology

Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal

Jianjiong Gao et al.

SCIENCE SIGNALING (2013)

Article Biochemistry & Molecular Biology

Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/β-TrCP Axis

Patricia Rada et al.

MOLECULAR AND CELLULAR BIOLOGY (2012)

Review Oncology

The Keap 1-Nrf2 system in cancers: stress response and anabolic metabolism

Yoichiro Mitsuishi et al.

FRONTIERS IN ONCOLOGY (2012)

Review Pharmacology & Pharmacy

Molecular Basis of Electrophilic and Oxidative Defense: Promises and Perils of Nrf2

Qiang Ma et al.

PHARMACOLOGICAL REVIEWS (2012)

Review Oncology

NRF2 and cancer: the good, the bad and the importance of context

Michael B. Sporn et al.

NATURE REVIEWS CANCER (2012)

Article Oncology

Keap1 Mutations and Nrf2 Pathway Activation in Epithelial Ovarian Cancer

Panagiotis A. Konstantinopoulos et al.

CANCER RESEARCH (2011)

Article Biochemistry & Molecular Biology

Predicting the functional impact of protein mutations: application to cancer genomics

Boris Reva et al.

NUCLEIC ACIDS RESEARCH (2011)

Article Multidisciplinary Sciences

Reactive oxygen species are indispensable in ovulation

Ketty Shkolnik et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Pathology

Oxidative Stress A Required Condition for Thyroid Cell Proliferation

Sylvie Poncin et al.

AMERICAN JOURNAL OF PATHOLOGY (2010)

Review Oncology

Nrf2: friend or foe for chemoprevention?

Thomas W. Kensler et al.

CARCINOGENESIS (2010)

Article Oncology

Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin

Yoo Ri Kim et al.

JOURNAL OF PATHOLOGY (2010)

Article Endocrinology & Metabolism

Minimal oxidative load: a prerequisite for thyroid cell function

Sylvie Poncin et al.

JOURNAL OF ENDOCRINOLOGY (2009)

Article Multidisciplinary Sciences

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

David A. Barbie et al.

NATURE (2009)

Review Biochemistry & Molecular Biology

NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

John D. Hayes et al.

TRENDS IN BIOCHEMICAL SCIENCES (2009)

Article Multidisciplinary Sciences

Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Tatsuhiro Shibata et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)

Article Biochemistry & Molecular Biology

A mutation of Keap1 found in breast cancer impairs its ability to repress Nrf2 activity

Paul Nioi et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Medicine, General & Internal

Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer

Anju Singh et al.

PLOS MEDICINE (2006)

Letter Genetics & Heredity

GenePattern 2.0

M Reich et al.

NATURE GENETICS (2006)

Article Biochemistry & Molecular Biology

Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model

KI Tong et al.

MOLECULAR AND CELLULAR BIOLOGY (2006)

Review Endocrinology & Metabolism

Fundamental roles of reactive oxygen species and protective mechanisms in the female reproductive system

J Fujii et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2005)

Article Multidisciplinary Sciences

Modifying specific cysteines of the electrophile-sensing human Keap1 disrupt binding to the protein is insufficient to Nrf2 domain Neh2

AL Eggler et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Cell Biology

Function and regulation of Cullin-RING ubiquitin ligases

MD Petroski et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)

Article Multidisciplinary Sciences

Protection against electrophile and oxidant stress by induction of the phase 2 response: Fate of cysteines of the Keap1 sensor modified by inducers

N Wakabayashi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate for proteasomal degradation of Nrf2

A Kobayashi et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex

DD Zhang et al.

MOLECULAR AND CELLULAR BIOLOGY (2004)

Article Biochemistry & Molecular Biology

BTB/POZ domain proteins are putative substrate adaptors for cullin 3 ubiquitin ligases

R Geyer et al.

MOLECULAR CELL (2003)

Article Multidisciplinary Sciences

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

AT Dinkova-Kostova et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)