期刊
BIOMED RESEARCH INTERNATIONAL
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/382063
关键词
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资金
- Sunil Kumar with Career Award for Young Teachers [151/RID/CA/4/2009-10]
Aims. This study was designed to investigate the enzyme inhibitory and antidiabetic activity for the constituents isolated from Dillenia indica. Methods. The leaves of D. indica were extracted withmethanol and subjected to fractionation and chromatographic separation, which led to the isolation of seven compounds: betulinic acid (1), n-heptacosan-7-one (2), n-nonatriacontan-18-one (3), quercetin (4),.. sitosterol (5), stigmasterol (6), and stigmasteryl palmitate (7). Among these isolates, compounds 1, 4, 5, and 6 were evaluated for in vitro enzyme inhibition and compounds 4, 5 and 6 were evaluated for antidiabetic activity in streptozotocinnicotinamide induced diabetic mice. Results. Compounds 1, 4, 5, and 6 showed 47.4, 55.2, 48.8, and 44.3%.. -amylase inhibition, respectively, and 52.2, 78.2, 52.5, and 34.2% mu-glucosidase inhibition, respectively, at the dose of 50.. g/ kg. Compounds 4, 5 and 6 also showed significant (P < 0.05) antidiabetic activity in streptozotocin-nicotinamide induced diabetic mice at the dose of 10 mg/ kg. Conclusion. These results provide evidence that Dillenia indica might be a potential source of antidiabetic agents.
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