期刊
BIOMED RESEARCH INTERNATIONAL
卷 2013, 期 -, 页码 -出版社
HINDAWI LTD
DOI: 10.1155/2013/101805
关键词
-
资金
- National Natural Science Foundation of China [81273289/H1008]
- Shanxi Scholarship council of China [2008102]
Objectives. To study effects of 1,25-dihydroxyvitamin D3 (1,25(OH)(2)D-3) on RANKL signaling pathway and pathway-associated cytokines in patients with rheumatoid arthritis (RA). Methods. Receptor activator of nuclear factor-kappa B ligand (RANKL), osteoprotegerin (OPG), IFN-gamma, IL-6, TNF-alpha, IL-17, and IL-4 were examined in 54 patients with incipient RA using a cytometric bead array (CBA) or an enzyme-linked immunosorbent assay (ELISA). Results. After 72 hours of incubation of peripheral blood mononuclear cells (PBMCs) with 1,25(OH)(2)D-3 in RA patients, the levels of RANKL, TNF-alpha, IL-17 and IL-6 significantly decreased compared to those of the control. 1,25(OH)(2)D-3 had no significantly impact on the levels of OPG, RANKL/OPG, and IL-4. Conclusions. The present study demonstrated that 1,25(OH)(2)D-3 reduced the production of RANKL and the secretion of TNF-alpha, IL-17, and IL-6 in PBMCs of RA patients, which indicated that 1,25(OH)(2)D-3 might be able to decrease damage of cartilage and bone in RA patients by regulating the expression of RANKL signaling pathway and pathway-associated cytokines.
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