期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 7, 期 9, 页码 1819-1824出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201800346
关键词
AChE inhibition; arenes; chalcogens; green chemistry; selenides
资金
- CAPES
- CNPq
- CERSusChem GSK/FAPESP [2014/50249-8]
- INCT-Catalise
- FAPESC-Pronex
Highly efficient KIO3-catalyzed chalcogenations (S and Se) of (hetero)arenes, with easily accessible and odorless dichalcogenides, were obtained through direct C(sp(2))-H bond chalcogenation. Using this benign, atom-economic protocol, the desired products were obtained regioselectively in good to excellent yields in the presence of ethylene glycol (4 equiv.) and KIO3 (20 mol%) as a non-toxic and easily handled catalyst. This metal- and solvent-free approach is scalable, and it is applicable to different types of (hetero)arenes. Furthermore, several of these chalcogenated (hetero)arenes exhibited a significantly high percentage of AChE inhibition, revealing their potential anti-Alzheimer activity.
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