期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 3, 期 6, 页码 711-714出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201402050
关键词
allylation; amines; H-phosphinic acids; hypophosphorous acid; palladium
资金
- National Natural Science Foundation of China [21232007, 21172206]
- National Key Basic Research Program of China [2014CB931800]
- Program for Changjiang Scholars and Innovative Research Team in University [IRT1189]
Primary allylic amines serve as suitable allylic electrophiles for the allylation reactions of hypophosphorous acid and H-phosphinic acids. In the presence of tris(dibenzylideneacetone)dipalladium(0) ([Pd-2(dba)(3)], 0.1 mol %) and Xantphos (0.2 mol %), aqueous hypophos-phorous acid was allylated by alpha-unbranched primary allylic amines in a highly regioselective fashion to give structurally diverse allylic H-phosphinic acids in good to excellent yields with exclusive E selectivity. Moreover, increasing the catalyst loading to 1 mol % and adding aqueous phosphoric acid (1.2 equiv.) permitted the allylation of H-phosphinic acids with alpha-unbranched primary allylic amines to proceed to give disubstituted phosphinic acids in good to excellent yields.
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