期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 4, 期 3, 页码 226-232出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201402146
关键词
amphiphilic block copolymers; doxorubicin; drug delivery; folic acid; micelles
资金
- National Research Foundation (NRF)
- Prime Minister's Office, Singapore under its NRF Fellowship [NRF2009NRF-RF001-015]
- Campus for Research Excellence and Technological Enterprise (CREATE) Programme-Singapore Peking University Research Centre for a Sustainable Low-Carbon Future
- NTU-A*Star Centre of Excellence for Silicon Technologies (A*Star SERC) [112 351 0003]
Intracellular, reduction-responsive, amphiphilic, copolymer micelles with cancer cell specificity were developed. The copolymer was prepared with controlled molecular weight and functionalities using a double-headed initiator consisting of a disulfide linkage and folic acid targeting unit. The polymer could self-assemble into spherical micelles, which were stable under physiological conditions. Anticancer drug doxorubicin (DOX) was encapsulated into the micelles during the micellization and then released rapidly into the environment under the stimulus of intracellular reducing agent glutathione. Flow cytometry and confocal laser scanning microscopy observations further indicated that DOX was successfully released from the internalized micelles into the cytoplasm, inducing apoptosis and cell death. The potential of the present copolymer micelles for application as anticancer drug carriers for targeted cancer therapy is promising.
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