期刊
ASIAN JOURNAL OF ORGANIC CHEMISTRY
卷 2, 期 8, 页码 624-636出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ajoc.201300018
关键词
arylation; C-H activation; heterocycles; nitrogen ligands; palladium
资金
- MEXT [2105]
- Grants-in-Aid for Scientific Research [25105718] Funding Source: KAKEN
Significant progress has been made in transition-metal-catalyzed direct functionalization of heteroarenes since the beginning of the 21st century. Particularly, palladium-catalyzed direct C-H arylations of heteroarenes have been extensively studied. Although a variety of catalytic systems have been applied in these reactions, phosphine-based ligands have mainly been used, and low reactivity at some positions, such as at the C4 position of azoles and the C3 position of heteroles, has remained a problem. Recently, the application of nitrogen-based ligands in palladium-catalyzed direct C-H arylations has attracted significant attention because the resulting catalytic systems are uniquely reactive. This Focus Review discusses recent advances in the use of palladium/nitrogen-based ligand systems for direct C-H arylation of heteroarenes.
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