Organometallic Approaches for Direct Modification of Peripheral C-H Bonds in Porphyrin Cores

Porphyrins play vital roles in living systems as well as in advanced organic materials science. Efficient synthesis of porphyrins and creation of novel porphyrins are thus important. Recently, organometallic chemistry has become more powerful and is now sophisticated enough to modify porphyrin C-H bonds directly, efficiently, and selectively. This Focus Review discusses methods for modifying peripheral porphyrin C-H bonds, specifically direct metalations and C-C bond formations.