Copper(I)-Catalyzed Boron Addition Reactions of Alkynes with Diboron Reagents

The development of catalytic Cu-B additions to carbon-carbon unsaturated bonds (borylcupration) with high regio- and stereoselectivity has enabled facile and direct syntheses of alkenylboronic esters, which are versatile synthetic intermediates in organic synthesis. An increasing number of relevant reactions have been reported over the past several years, which can be categorized based on the electrophilic reagent that reacts with the common alkenylcopper intermediates that are generated insitu by Cu-B addition to alkynes. In this Focus Review, recent advances in copper-catalyzed boron addition reactions for the synthesis of alkenylboronic esters with diboron reagents are summarized.