期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 44, 期 2, 页码 550-558出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2014.968822
关键词
biodegradable; poly (D,L-lactic-co-glycolic acid); magnetic nanoparticles; doxorubicin
资金
- Department of Medical Nanotechnology, Faculty of Advanced Medical Science of Tabriz University
Magnetic nanoparticles are a main class of nanoscale materials with the potential to revolutionize present clinical therapeutic and diagnostic techniques. Functionalization of magnetic nanoparticles with copolymers, different surfactants, or other organic compounds is usually done in order to achieve better physicochemical properties. Poly (D,L-lactic-co-glycolic acid) (PLGA) polymers have been extensively used as biodegradable carriers for drug delivery. These biodegradable aliphatic polyesters, with proven biocompatibility, have versatile biodegradation properties, depending on their molecular weight and chemical composition. The aim of the present work was to assess the merits of Fe-3 O-4-PLGA-PEG nanoparticles as anticancer drug carriers. For this purpose, magnetic Fe3O4 nanoparticles were first prepared, and then the copolymer PLGA-PEG was synthesized with polyethylene glycol (PEG) of various molecular weights. The copolymer was con?rmed with Fourier transform infrared (FTIR) spectra. Doxorubicin was encapsulated within nanoparticles made of Fe3O4-PLGA-PEG, using the double emulsion method (w/o/w). The nanoparticles were characterized in terms of size, and the in vitro release of doxorubicin.
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