期刊
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
卷 43, 期 4, 页码 263-269出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/21691401.2014.885442
关键词
cytotoxicity; degree of swelling; electrospinning; mucoadhesive patch; nanofibers
The aim of the present study is to design a mucoadhesive nano-carrier system which retains at the site of application and maximizes the therapeutic potential of anticancer drug as well as reduces their systemic side effects. In the present study PVA nanofibers of Docetaxel were prepared using electrospinning machine. The resulting nanofibers were characterized through various parameters such as surface morphology, drug loading, in-vitro drug release, tensile strength, mucoadhesiveness, drug permeability, degree of swelling and anticancer activities against selective cell lines to establish their therapeutics potential. On the basis of various evaluation results, we may conclude that the current approach comprising polymeric nanofibers can be successfully used for local delivery of anticancer drug.
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