期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 11, 期 -, 页码 773-783出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.11.87
关键词
biomaterials; growth factor; integrin; osteodifferentiation; stem cells
资金
- Deutsche Forschungsgemeinschaft [DFG SFB TRR79 TPM9]
- Max Planck Society
Stem cells respond to the microenvironment (niche) they are located in. Under natural conditions, the extracellular matrix (ECM) is the essential component the in stem cell niche, in which both integrin ligands and growth factors are important regulators to directly or indirectly modulate the cell behavior. In this review, we summarize the current knowledge about the potential of integrin ligands and growth factors to induce osteogenic differentiation of stem cells, and discuss the signaling pathways that are initiated by both individual and cooperative parameters. The joint effect of integrin ligands and growth factors is highlighted as the multivalent interactions for bone therapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据