期刊
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
卷 18, 期 4, 页码 301-310出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/PAI.0b013e3181cf1126
关键词
MUM1/IRF4; multiple myeloma oncogene 1; lymphocyte-specific interferon regulatory factor; LSIRF; immunohistochemistry; lymphoma
MUM1/IRF4 protein is a member of the interferon regulatory factor (IRF) family of transcriptional factors initially described as downstream regulators of interferon signaling. The quantity of this factor varies within the hematopoietic system in a lineage and stage-specific way. It is considered to be a key regulator of several steps in lymphoid, myeloid, and dendritic cell differentiation and maturation. MUM1/IRF4 expression is observed in many lymphoid and myeloid malignancies, and may be a promising target for the treatment of some of these neoplasms. We reviewed the literature on MUM1/IRF4, with emphasis on the pathologic aspects of this marker in reactive and malignant hematologic and nonhematologic conditions.
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