期刊
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 2
卷 2, 期 -, 页码 23-40出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-animal-022513-114144
关键词
genomic imprinting; epigenetics; cattle; sheep; pigs; horses
The mouse is the first species in which genomic imprinting was studied. Imprinting research in farm species has lagged behind owing to a lack of sequencing and genetic background information, as well as long generation intervals and high costs in tissue collection. Since the creation of Dolly, the first cloned mammal from an adult sheep, studies on genomic imprinting in domestic species have accelerated because animals from cloning and other assisted reproductive technologies exhibit phenotypes of imprinting disruptions. Although this review focuses on new developments in farm animals, most of the imprinting mechanism information was derived from the mouse.
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