期刊
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
卷 37, 期 2, 页码 117-122出版社
INFORMA HEALTHCARE
DOI: 10.3109/00952990.2010.543204
关键词
cocaine; attentional bias; impulsivity; inhibitory control
资金
- NIDA NIH HHS [K05 DA020087-05, P20 DA024157-04, P50 DA009262, K05 DA020087, P20 DA024157, K05 DA020087-05S1, P50DA009262, P50 DA009262-15, P20DA024157, K05 DA020087-03, K05 DA020087-01, K05 DA020087-04, K05 DA020087-02] Funding Source: Medline
Background: Cocaine-dependent subjects show attentional bias to cocaine-related stimuli, increased impulsivity on questionnaires, and impaired inhibitory control (one component of impulsivity on behavioral tasks). However, the relationship between attentional bias, impulsivity, and inhibitory control in cocaine-dependent subjects is unknown. Objective: To investigate the relationship between attentional bias to cocaine-related stimuli, impulsivity, and inhibitory control in cocaine dependence. Methods: This study employed the cocaine Stroop task to measure attentional bias to cocaine-related stimuli, immediate memory task (IMT) to measure inhibitory control, and Barratt Impulsiveness Scale version 11 to measure impulsivity. Thirty-two controls and 37 cocaine-dependent subjects were recruited through newspaper advertisement. Results: Cocaine-dependent subjects had higher attentional bias to cocaine-related words, higher scores for Barratt Impulsiveness Scale, and higher commission error rate on the IMT than controls. The attentional bias was positively correlated with the commission error rate on the IMT in the cocaine-dependent subjects but not in control subjects. Conclusions: Cocaine-dependent subjects showed attentional bias to cocaine-related words, increased impulsivity, and poor inhibitory control compared with controls. The attentional bias was associated with inhibitory control in cocaine-dependent subjects but not in control subjects. Scientific Significance: Our findings suggest that cocaine-dependent subjects with poor inhibitory control may show higher attentional bias to cocaine-related words compared with controls and those with better inhibitory control.
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