期刊
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
卷 34, 期 6, 页码 721-729出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/00952990802308262
关键词
aripiprazole; cocaine; pharmacotherapy; physiological effects; subjective effects
资金
- NCRR NIH HHS [M01 RR002602-225142, M01 RR002602, M01 RR02602] Funding Source: Medline
- NIDA NIH HHS [R01 DA020429, R01 DA020429-04, K01 DA018772, R01 DA 020429, K01 DA018772-04] Funding Source: Medline
- NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR002602] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON DRUG ABUSE [K01DA018772, R01DA020429] Funding Source: NIH RePORTER
Objectives: This experiment determined the safety and tolerability of intranasal cocaine during aripiprazole maintenance. Methods: Six cocaine-dependent human subjects were maintained on aripiprazole (15 mg) and placebo for 10 days in counterbalanced order prior to assessing the physiological and subject-rated effects of intranasal cocaine. Results: Intranasal cocaine produced prototypical stimulant-like effects (e.g., increased blood pressure and heart rate, increased subject ratings of Like Drug and Stimulated), and aripiprazole enhanced these effects on several measures. Conclusions: Aripiprazole (15 mg/day) is safe and tolerable when combined with cocaine; however, the usefulness of aripiprazole as a treatment for cocaine-use disorders remains to be determined.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据