期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 6, 期 11, 页码 15064-15071出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.8b03540
关键词
ROS generation; Bacteria killing; Aggregation-induced emission (AIE); Photodynamic therapy (PDT); Fluorescence imaging
资金
- National Natural Science Foundation of China [21764012]
- Key Laboratory of Eco-Environment-Related Polymer Materials (Northwest Normal University)
The newly emerged pathogenic bacteria leads to the bactericides generations one by one, which is definitely a long-term and costly process. For the small organic molecule used as antibacterial materials, photostability, biomembrane penetrating ability, and long-term antibacterial ability still are questionable. In this work, we synthesized the multiple-cation charged aggregation-induced emission (AIE)-active polymer 1,2-diphenyl-1,2-bis(4-(pyridin-4-yl)phenyl) ethane-1,8-dibromooctane (DBPE-DBO). Due to the incorporating the dark toxicity from positively charged polymers, and the photo-toxicity from generation of singlet oxygen, as well as AIE-active fluorescence performance, DBPE-DBO could be employed as an efficient bacteria targeting, imaging, and killing materials. Interestingly, DBPE-DBO was less toxic to the normal mammalian cells, which leads us to verify that DBPE-DBO could be used as a very cell-membrane permeable nucleus imaging probes. Thus, our research results may provide a new concept for the designing advanced biomaterials with versatile antibacterial properties and cell imaging ability.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据