Copper Nanoparticles Supported on Agarose as a Bioorganic and Degradable Polymer for Multicomponent Click Synthesis of 1,2,3-Triazoles under Low Copper Loading in Water

Agarose-supported copper nanoparticles (CuNPs@agarose) were prepared by immobilization of copper bromide on agarose followed by in situ chemical reduction. The new material was characterized by SEM, EDX, TEM, TGA, XRD, nitrogen adsorption-desorption, and solid UV-vis analysis. The catalytic activity of CuNPs@agarose was assessed in the three component click synthesis of 1,2,3-triazoles in water under low catalyst loading and mild reaction conditions. The easy synthesis and air-stable catalyst was recycled for five runs with small drops in catalytic activity.