期刊
TRANSPLANTATION REVIEWS
卷 26, 期 4, 页码 233-240出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.trre.2012.02.001
关键词
Efficacy; EC-MPS; Immunosuppression; MMF; Mycophenolic acid; Kidney transplant; GI tolerability
Mycophenolate mofetil (MMF), a mycophenolic acid (MPA) formulation, has improved both short- and long-term outcomes following renal transplantation, but is often associated with gastrointestinal (GI) complications that can lead to dose reduction or discontinuation, potentially jeopardizing patient outcomes. Enteric-coated mycophenolate sodium (EC-MPS) delivers equivalent MPA exposure to MMF and offers the potential to reduce GI burden (while maintaining patient safety). Here we review the efficacy of EC-MPS compared with MMF in renal transplant patients in terms of biopsy-proven acute rejection and graft loss, and examine the use of EC-MPS in newer regimens such as intensified dosing and calcineurin inhibitor minimization. (C) 2012 Elsevier Inc. All rights reserved.
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