期刊
TRANSLATIONAL STROKE RESEARCH
卷 4, 期 6, 页码 581-588出版社
SPRINGER
DOI: 10.1007/s12975-013-0299-5
关键词
Brain ischemia; Protein misfolding; Protein aggregation; Autophagy; Protein synthesis; Chaperone; Multiple organelle damage; Ubiquitin-proteasomal system
Ischemic brain injury is a common disorder linked to a variety of diseases. Significant progress has been made in our understanding of the underlying mechanisms. Previous studies show that protein misfolding, aggregation, and multiple organelle damage are major pathological events in postischemic neurons. The autophagy pathway is the chief route for bulk degradation of protein aggregates and damaged organelles. The latest studies suggest that impairment of autophagy contributes to abnormal protein aggregation and organelle damages after brain ischemia. This article reviews recent studies of protein misfolding, aggregation, and impairment of autophagy after brain ischemia.
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