期刊
TRANSLATIONAL STROKE RESEARCH
卷 4, 期 1, 页码 25-39出版社
SPRINGER
DOI: 10.1007/s12975-012-0226-1
关键词
Preconditioning; Traumatic brain injury; Neuroprotection; Pathophysiology
资金
- NINDS [RO1 NS 042133]
- Miami Project to Cure Paralysis
- General Insurance Association of Japan
Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and reduction of secondary injury. However, no single effective treatment is available as yet for the mitigation of traumatic brain damage in humans. Both chemical and environmental stresses applied before injury have been shown to induce consequent protection against post-TBI neuronal death. This concept termed preconditioning is achieved by exposure to different pre-injury stressors to achieve the induction of tolerance to the effect of the TBI. However, the precise mechanisms underlying this tolerance phenomenon are not fully understood in TBI, and therefore even less information is available about possible indications in clinical TBI patients. In this review, we will summarize TBI pathophysiology, and discuss existing animal studies demonstrating the efficacy of preconditioning in diffuse and focal type of TBI. We will also review other non-TBI preconditioning studies, including ischemic, environmental, and chemical preconditioning, which maybe relevant to TBI. To date, no clinical studies exist in this field, and we speculate on possible future clinical situations, in which pre-TBI preconditioning could be considered.
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