期刊
TOXINS
卷 6, 期 12, 页码 3568-3581出版社
MDPI
DOI: 10.3390/toxins6123568
关键词
Fischerella; Stigonemataceae; cyanobacteria; hapalindoles; ambiguines; indole alkaloids; zebrafish embryo; teratogenicity; vertebrate toxicity; harmful algal blooms
资金
- ARCH from National Institute of Environmental Health Sciences (NIEHS) of the US National Institutes of Health (NIH) [ES11181]
- National Institute of Environmental Health Sciences (NIEHS) of the US National Institutes of Health (NIH) [ES014 037]
- Oceans and Human Health Initiative from US National Oceanic and Atmospheric Administration [NA09NOS4730071]
Cyanobacteria are recognized producers of toxic or otherwise bioactive metabolite associated, in particular, with so-called harmful algal blooms (HABs) and eutrophication of freshwater systems. In the present study, two apparently teratogenic indole alkaloids from a freshwater strain of the widespread cyanobacterial genus, Fischerella (Stigonemataceae), were isolated by bioassay-guided fractionation, specifically using the zebrafish (Danio rerio) embryo, as a model of vertebrate development. The two alkaloids include the previously known 12-epi-hapalindole H isonitrile (1), and a new nitrile-containing variant, 12-epi-ambiguine B nitrile (2). Although both compounds were toxic to developing embryos, the former compound was shown to be relatively more potent, and to correlate best with the observed embryo toxicity. Related indole alkaloids from Fischerella, and other genera in the Stigonemataceae, have been widely reported as antimicrobial compounds, specifically in association with apparent allelopathy. However, this is the first report of their vertebrate toxicity, and the observed teratogenicity of these alkaloids supports a possible contribution to the toxicity of this widespread cyanobacterial family, particularly in relation to freshwater HABs and eutrophication.
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