相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。Clostridium difficile Toxin-Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome
Jeffrey Ng et al.
GASTROENTEROLOGY (2010)
Hypoxia-Inducible Factor Signaling Provides Protection in Clostridium difficile-Induced Intestinal Injury
Simon A. Hirota et al.
GASTROENTEROLOGY (2010)
Piglet Models of Acute or Chronic Clostridium difficile Illness
Jennifer Steele et al.
JOURNAL OF INFECTIOUS DISEASES (2010)
Four Distinct Structural Domains in Clostridium difficile Toxin B Visualized Using SAXS
David Albesa-Jove et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Serum anti-toxin B antibody correlates with protection from recurrent Clostridium difficile infection (CDI)
Brett A. Leav et al.
VACCINE (2010)
Clostridium difficile toxin A binds colonocyte Src causing dephosphorylation of focal adhesion kinase and paxillin
Ho Kim et al.
EXPERIMENTAL CELL RESEARCH (2009)
Melanin-concentrating hormone (MCH) modulates C difficile toxin A-mediated enteritis in mice
E. Kokkotou et al.
GUT (2009)
Antibiotic Treatment of Clostridium difficile Carrier Mice Triggers a Supershedder State, Spore-Mediated Transmission, and Severe Disease in Immunocompromised Hosts
Trevor D. Lawley et al.
INFECTION AND IMMUNITY (2009)
Structural Basis for Substrate Recognition in the Enzymatic Component of ADP-ribosyltransferase Toxin CDTa from Clostridium difficile
Amit Sundriyal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Structure-Function Analysis of Inositol Hexakisphosphate-induced Autoprocessing in Clostridium difficile Toxin A
Rory N. Pruitt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
An ultrasensitive rapid immunocytotoxicity assay for detecting Clostridium difficile toxins
Xianyun He et al.
JOURNAL OF MICROBIOLOGICAL METHODS (2009)
Clostridium difficile toxin A promotes dendritic cell maturation and chemokine CXCL2 expression through p38, IKK, and the NF-κB signaling pathway
Jin Young Lee et al.
JOURNAL OF MOLECULAR MEDICINE-JMM (2009)
Toxin B is essential for virulence of Clostridium difficile
Dena Lyras et al.
NATURE (2009)
Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages
Xingmin Sun et al.
MICROBIAL PATHOGENESIS (2009)
Clostridium difficile Toxin CDT Induces Formation of Microtubule-Based Protrusions and Increases Adherence of Bacteria
Carsten Schwan et al.
PLOS PATHOGENS (2009)
Tolevamer, an anionic polymer, neutralizes toxins produced by the BI/027 strains of Clostridium difficile
Paul L. Hinkson et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)
Aerial Dissemination of Clostridium difficile spores
Katherine Roberts et al.
BMC INFECTIOUS DISEASES (2008)
Essential role of toxin A in C-difficile 027 and reference strain supernatant-mediated disruption of Caco-2 intestinal epithelial barrier function
P. A. Sutton et al.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2008)
Emerging toxin A-B plus variant strain of Clostridium difficile responsible for pseudomembranous colitis at a tertiary care hospital in Korea
Bo-Moon Shin et al.
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE (2008)
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
Ismael Halabi-Cabezon et al.
FEBS LETTERS (2008)
A Mouse Model of Clostridium difficile-Associated Disease
Xinhua Chen et al.
GASTROENTEROLOGY (2008)
Human α-defensins inhibit Clostridium difficile toxin B
Torsten Giesemann et al.
GASTROENTEROLOGY (2008)
gp96 is a human colonocyte plasma membrane binding protein for Clostridium difficile toxin A
Xi Na et al.
INFECTION AND IMMUNITY (2008)
Role of phospholipase A2 and tyrosine kinase in Clostridium difficile toxin A-induced disruption of epithelial integrity, histologic inflammatory damage and intestinal secretion
Aldo A. M. Lima et al.
JOURNAL OF APPLIED TOXICOLOGY (2008)
Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells
Ralf Gerhard et al.
JOURNAL OF MEDICAL MICROBIOLOGY (2008)
Structure and mode of action of clostridial glucosylating toxins: the ABCD model
Thomas Jank et al.
TRENDS IN MICROBIOLOGY (2008)
Open-label, dose escalation phase I study in healthy volunteers to evaluate the safety and pharmacokinetics of a human monoclonal antibody to Clostridium difficile toxin A
Claribel P. Taylor et al.
VACCINE (2008)
Heterogeneity of large clostridial toxins:: importance of Clostridium difficile toxinotypes
Maja Rupnik
FEMS MICROBIOLOGY REVIEWS (2008)
C-terminal repeats of Clostridium difficile toxin A induce production of chemokine and adhesion molecules in endothelial cells and promote migration of leukocytes
Chiou-Yueh Yeh et al.
INFECTION AND IMMUNITY (2008)
Clostridium difficile glucosyltransferase toxin B-essential amino acids for substrate binding
Thomas Jank et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Binary toxin production in Clostridium difficile is regulated by CdtR, a LytTR family response regulator
Glen P. Carter et al.
JOURNAL OF BACTERIOLOGY (2007)
A comparison of vancomycin and metronidazole for the treatment of Clostridium difficile -: Associated diarrhea, stratified by disease severity
Fred A. Zar et al.
CLINICAL INFECTIOUS DISEASES (2007)
Clostridium difficile toxins A and B directly stimulate human mast cells
Gesa K. A. Meyer et al.
INFECTION AND IMMUNITY (2007)
Clostridium difficile-associated diarrhoea
B. Elliott et al.
INTERNAL MEDICINE JOURNAL (2007)
The challenges posed by reemerging Clostridium difficile infection
David B. Blossom et al.
CLINICAL INFECTIOUS DISEASES (2007)
Clostridium difficile:: Recent epidemiologic findings and advances in therapy
Nicole L. McMaster-Baxter et al.
PHARMACOTHERAPY (2007)
Prevalence of Clostridium difficile environmental contamination and strain variability in multiple health care facilities
Erik R. Dubberke et al.
AMERICAN JOURNAL OF INFECTION CONTROL (2007)
Protease-activated receptor 2, dipeptidyl peptidase 1, and proteases mediate Clostridium difficile toxin A enteritis
Graeme S. Cottrell et al.
GASTROENTEROLOGY (2007)
Clostridium difficile toxin B causes apoptosis in epithelial cells by thrilling mitochondria -: Involvement of ATP-sensitive mitochondrial potassium channels
Paola Matarrese et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Autocatalytic cleavage of Clostridium difficile toxin
Jessica Reineke et al.
NATURE (2007)
Variant forms of the binary toxin CDT locus and tcdC gene in Clostridium difficile strains
Barbara Geric Stare et al.
JOURNAL OF MEDICAL MICROBIOLOGY (2007)
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470
Johannes Huelsenbeck et al.
INFECTION AND IMMUNITY (2007)
Toxin A-negative, toxin B-positive Clostridium difficile
Denise Drudy et al.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES (2007)
Rho-glucosylating Clostridium difficile toxins A and B: new insights into structure and function
Thomas Jank et al.
GLYCOBIOLOGY (2007)
Narrative review: The new epidemic of clostridium difficile-associated enteric disease
John G. Bartlett
ANNALS OF INTERNAL MEDICINE (2006)
Human monoclonal antibodies directed against toxins A and B prevent Clostridium difficile-induced mortality in hamsters
Gregory J. Babcock et al.
INFECTION AND IMMUNITY (2006)
Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects
Matthias Teichert et al.
INFECTION AND IMMUNITY (2006)
Identification of Clostridium difficile toxin B cardiotoxicity using a zebrafish embryo model of intoxication
Elaine E. Hamm et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Corticotropin-releasing hormone receptor 2-deficient mice have reduced intestinal inflammatory responses
Efi Kokkotou et al.
JOURNAL OF IMMUNOLOGY (2006)
Epithelial cell IκB-kinase β has an important protective role in Clostridium difficile toxin A-induced mucosal injury
Sungwon Chae et al.
JOURNAL OF IMMUNOLOGY (2006)
NF-κB activation pathway is essential for the chemokine expression in intestinal epithelial cells stimulated with Clostridium difficile toxin A
J. M. Kim et al.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2006)
The comparative pathology of Clostridium difficile-associated disease
M. K. Keel et al.
VETERINARY PATHOLOGY (2006)
Carbohydrate recognition by Clostridium difficile toxin A
A Greco et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Cholesterol-dependent pore formation of Clostridium difficile toxin A
T Giesemann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Binary toxin-producing, large clostridial toxin-negative Clostridium difficile strains are enterotoxic but do not cause disease in hamsters
B Geric et al.
JOURNAL OF INFECTIOUS DISEASES (2006)
Toxigenic C-difficile induced inflammatory marker expression by human intestinal epithelial cells is asymmetrical
G Canny et al.
LIFE SCIENCES (2006)
Crystal structure of receptor-binding C-terminal repeats from Clostridium difficile toxin A
JGS Ho et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A predominantly clonal multi-institutional outbreak of Clostridium difficile-associated diarrhea with high morbidity and mortality
VG Loo et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
An epidemic, toxin gene-variant strain of Clostridium difficile
LC McDonald et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
Human mucosa/submucosa interactions during intestinal inflammation: involvement of the enteric nervous system in interleukin-8 secretion
E Tixier et al.
CELLULAR MICROBIOLOGY (2005)
Clostridium difficile toxin A-induced colonocyte apoptosis involves p53-dependent p21(WAF1/CIP1) induction via p38 mitogen-activated protein kinase
H Kim et al.
GASTROENTEROLOGY (2005)
Structural basis for the function of Clostridium difficile toxin B
DJ Reinert et al.
JOURNAL OF MOLECULAR BIOLOGY (2005)
Angiotensin II subtype 1 receptor blockade inhibits Clostridium difficile toxin A-induced intestinal secretion in a rabbit model
CS Alcantara et al.
JOURNAL OF INFECTIOUS DISEASES (2005)
Clostridium difficile toxin A regulates inducible cyclooxygenase-2 and prostaglandin E2 synthesis in colonocytes via reactive oxygen species and activation of p38 MAPK
H Kim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Pathogenesis and treatment of Clostridium difficile infection
I Tonna et al.
POSTGRADUATE MEDICAL JOURNAL (2005)
Passive immunisation of hamsters against Clostridium difficile infection using antibodies to surface layer proteins
JB O'Brien et al.
FEMS MICROBIOLOGY LETTERS (2005)
The role of leukotriene B4 in Clostridium difficile toxin A-induced ileitis in rats
DC McVey et al.
GASTROENTEROLOGY (2005)
Clostridium difficile toxins:: Mechanism of action and role in disease
DE Voth et al.
CLINICAL MICROBIOLOGY REVIEWS (2005)
Clostridium difficile toxin B activates the EGF receptor and the ERK/MAP kinase pathway in human colonocytes
X Na et al.
GASTROENTEROLOGY (2005)
Monocytes are highly sensitive to Clostridium difficile toxin A-induced apoptotic and nonapoptotic cell death
K Solomon et al.
INFECTION AND IMMUNITY (2005)
Clostridium difficile toxoid vaccine in recurrent C-difficile-associated diarrhea
S Sougioultzis et al.
GASTROENTEROLOGY (2005)
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
JH Niess et al.
SCIENCE (2005)
Secular trends in hospital-acquired Clostridium difficile disease in the United States, 1987-2001
LK Archibald et al.
JOURNAL OF INFECTIOUS DISEASES (2004)
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B
H Hayashi et al.
JOURNAL OF GENERAL PHYSIOLOGY (2004)
Prevalence and characterization of a binary toxin (actin-specific ADP-ribosyltransferase) from Clostridium difficile
C Gonçalves et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2004)
Essential involvement of IFN-γ in Clostridium difficile toxin A-induced enteritis
Y Ishida et al.
JOURNAL OF IMMUNOLOGY (2004)
Rifalazil treats and prevents relapse of Clostridium difficile-associated diarrhea in hamsters
PM Anton et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2004)
Differential effects of varying concentrations of Clostridium difficile toxin A on epithelial barrier function and expression of cytokines
SS Johal et al.
JOURNAL OF INFECTIOUS DISEASES (2004)
Corticotropin-releasing hormone (CRH) requirement in Clostridium difficile toxin A-mediated intestinal inflammation
PM Anton et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Cellular uptake of Clostridium difficile toxin B -: Translocation of the N-terminal catalytic domain into the cytosol of eukaryotic cells
G Pfeifer et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Clostridium difficile toxin B is an inflammatory enterotoxin in human intestine
TC Savidge et al.
GASTROENTEROLOGY (2003)
Clostridium difficile colitis causing toxic megacolon, severe sepsis and multiple organ dysfunction syndrome
G Dobson et al.
INTENSIVE CARE MEDICINE (2003)
R-Ras glucosylation and transient RhoA activation determine the cytopathic effect produced by toxin B variants from toxin A-negative strains of Clostridium difficile
E Chaves-Olarte et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Toxin B of Clostridium difficile activates human VIP submucosal neurons, in part via an IL-1 beta-dependent pathway
M Neunlist et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Frequency of binary toxin genes among Clostridium difcile strains that do not produce large clostridial toxins
B Geric et al.
JOURNAL OF CLINICAL MICROBIOLOGY (2003)
Human intestinal epithelial and smooth muscle cells are potent producers of IL-6
EK Ng et al.
MEDIATORS OF INFLAMMATION (2003)
Mechanism of Clostridium difficile toxin A-induced apoptosis in T84 cells
GAC Brito et al.
JOURNAL OF INFECTIOUS DISEASES (2002)
Binding of Clostridium difficile surface layer proteins to gastrointestinal tissues
E Calabi et al.
INFECTION AND IMMUNITY (2002)
Rho protein inactivation induced apoptosis of cultured human endothelial cells
S Hippenstiel et al.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY (2002)
Corticotropin-releasing hormone antagonists possess anti-inflammatory effects in the mouse ileum
M Wlk et al.
GASTROENTEROLOGY (2002)
Clostridium difficile toxin B activates dual caspase-dependent and caspase-independent apoptosis in intoxicated cells
M Qa'Dan et al.
CELLULAR MICROBIOLOGY (2002)
Clostridium difficile toxin A triggers human colonocyte IL-8 release via mitochondrial oxygen radical generation
D He et al.
GASTROENTEROLOGY (2002)
Protein kinase C signaling regulates ZO-1 translocation and increased paracellular flux of T84 colonocytes exposed to Clostridium difficile toxin A
ML Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Differential expression and polarized secretion of CXC and CC chemokines by human intestinal epithelial cancer cell lines in response to Clostridium difficile toxin A
JM Kim et al.
MICROBIOLOGY AND IMMUNOLOGY (2002)
Fatal pseudomembranous colitis associated with a variant Clostridium difficile strain not detected by toxin a immunoassay
S Johnson et al.
ANNALS OF INTERNAL MEDICINE (2001)
Role of inducible cyclooxygenase and prostaglandins in Clostridium difficile toxin A-induced secretion and inflammation in an animal model
C Alcantara et al.
JOURNAL OF INFECTIOUS DISEASES (2001)
Microbes and microbial toxins:: Paradigms for microbial-mucosal interactions -: II.: The integrated response of the intestine to Clostridium difficile toxins
C Pothoulakis et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2001)
Safety and immunogenicity of increasing doses of a Clostridium difficile toroid vaccine administered to healthy adults
KL Kotloff et al.
INFECTION AND IMMUNITY (2001)
Clostridium difficile toxins A and B can alter epithelial permeability and promote bacterial paracellular migration through HT-29 enterocytes
BA Feltis et al.
SHOCK (2000)
Activation of MMP-2 by Clostridium difficile toxin B in bovine smooth muscle cells
T Koike et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2000)
p38 MAP kinase activation by Clostridium difficile toxin A mediates monocyte necrosis, IL-8 production, and enteritis
M Warny et al.
JOURNAL OF CLINICAL INVESTIGATION (2000)
Chemokines and dendritic cell traffic
S Sozzani et al.
JOURNAL OF CLINICAL IMMUNOLOGY (2000)
pH-induced conformational changes in Clostridium difficile toxin B
M Qa'Dan et al.
INFECTION AND IMMUNITY (2000)
Clostridium difficile recombinant toxin A repeating units as a carrier protein for conjugate vaccines:: Studies of pneumococcal type 14, Escherichia coli K1, and Shigella flexneri type 2a polysaccharides in mice
D Pavliakova et al.
INFECTION AND IMMUNITY (2000)
Polymeric IgA is superior to monomeric IgA and IgG carrying the same variable domain in preventing Clostridium difficile toxin A damaging of T84 monolayers
H Stubbe et al.
JOURNAL OF IMMUNOLOGY (2000)
Asymptomatic carriage of Clostridium difficile and serum levels of IgG antibody against toxin A.
L Kyne et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
In vitro and in vivo activities of nitazoxanide against Clostridium difficile
CS McVay et al.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2000)