期刊
TOXINS
卷 2, 期 2, 页码 283-296出版社
MDPI AG
DOI: 10.3390/toxins2020282
关键词
CNF1; Escherichia coli; memory; vaccine adjuvant; drug delivery agent; pain
CNF1 is a protein toxin produced by certain pathogenic strains of Escherichia coli. It permanently activates the regulatory Rho, Rac, and Cdc42 GTPases in eukaryotic cells, by deamidation of a glutamine residue. This modification promotes new activities in cells, such as gene transcription, cell proliferation and survival. Since the Rho GTPases play a pivotal role also in several processes in vivo, the potentiality of CNF1 to act as a new pharmacological tool has been explored in experimental animals and in diverse pathological contexts. In this review, we give an update overview on the potential in vivo applications of CNF1.
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